It was a case that gripped the nation. In December 2003, Luke Ryder, the stepfather of acclaimed filmmaker Guy Howard (then aged 10), was found dead in the garden of their suburban family home. Luke Ryder's murder has never been solved. Everyone present around the time of the murder swears they saw nothing. Despite a high-profile police investigation and endless media attention, no suspect was ever charged.

Computational biologist and serial-killer hunter Dr. Theo Cray receives an off-the-record request from the FBI to investigate an inexplicable double homicide. It happened at the excavation site where a murderer had buried his victims’ remains. In custody is a forensic technician in shock, with no history of aggression. He doesn’t remember a thing. His colleagues don’t even recognize the man they thought they knew. But an MRI reveals something peculiar. And abnormal.